|
KMID : 0370220100540060466
|
|
Yakhak Hoeji
2010 Volume.54 No. 6 p.466 ~ p.473
|
|
|
Synthesis and -Reductase Inhibitory Activity of -Substituted 5-Androstene-17-Carboxamides
|
|
Jo Ik-Sung
Ma Eun-Sook
|
|
|
Abstract
|
|
|
|
A series of -substituted 5-androstene--carboxamides were synthesized from analogs of -hydroxy-5-androstene--carboxylic acid (1) with tert-butylamine, N,N-diethylamine and 3-aminopyridine and some compounds were epoxidized with mCPBA. A rat prostate testosterone -reductase inhibitory activity of synthesized compounds was assessed by radioimmunoassay using [1,2,6,7-3H]-testosterone as substrate. All synthesized compounds showed lower activity than finasteride and the N-(3-pyridino)--carboxycarbonyloxy-5-androstene--carboxamide (12) showed weak inhibitory activity (: ).
|
|
|
KEYWORD
|
|
|
-reductase inhibitor, prostate cancer, benign prostatic hyperplasia, -substituted 5-androstene--carboxamide
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|